Phase I and II detoxification is known to be a vital aspect of preventing the accumulation of toxins in the body, and neutralizing and eliminating various cancer-causing agents and procarcinogens. Among other functions, liver cells are capable of detoxifying a large number of end-products of metabolism, drugs, xenbiotics, hormones and other compounds, including certain carcinogens. Almost two quarts of blood pass through the liver every minute of our lives. The liver and epithelial cells of the intestinal tract contain the major detoxification centers in of the body, referred to as phase I and II detoxification. 10,11 I3C and other glucosinolates (e.g., other indoles and isothiocyanates, such as sulforphane) are antioxidants and potent stimulators of phase I and II detoxification enzymes in the liver and intestinal epithelial cells. 9 It is formed from parent compounds whenever cruciferous vegetables are crushed or cooked. 1-8 I3C is a member of the class of sulfurous chemicals called glucosinolates (previously called thioglucosides). Frequent consumption of cruciferous vegetables is associated with reduced risk of cancer in many human epidemiological studies and in animal experiments. I3C has been shown to be one of the major anti-cancer substances found in cruciferous vegetables. This important biological agent is known to speed up the detoxification of many potentially harmful chemicals (including carcinogens) provide antioxidant support block the overproduction of certain hormones that are linked to increased risk of breast and prostate cancer and act as a phytoestrogen (plant-based estrogen) that can bind to estrogen receptors on reproductive tissue and exert anti-cancer influences. One of the less appreciated bioactive agents strongly associated with reducing risk of many common cancers is indole-3-carbinol (I3C), found exclusively in cruciferous vegetables (broccoli, cauliflower, cabbage, Brussels sprouts, kale and bok choy), and in various supplements. Non-medicinal: Microcrystalline cellulose, Hypromellose (capsule).There is a growing awareness among health practitioners and the general public about the importance of nutrition and antioxidants, flavonoids, soy isoflavones and dietary fiber.Medicinal: Indole-3-Carbinol (I3C): 200 mg.Reduces the formation of harmful estrogens.I-3-C may also be a beneficial supplement for those who want to reap some of the benefits of cruciferous vegetables like broccoli but have difficulty eating it raw. Women who are concerned with estrogen metabolism, who have a family history, or increased risk, or have a higher ratio of bad to good estrogens can benefit from the addition of I-3-C. Estrogen dominance has been linked to fibroids, breast tenderness, premenstrual syndrome, endometriosis and health problems in women. Studies targeting women taking I-3-C have demonstrated a favorable change in estrogen metabolism and that I-3-C has a protective effect against estrogen dominance in women. Studies have shown that by altering the balance of metabolic enzymes that process estrogen, I-3-C reduces the formation of "bad" estrogen and increases the formation of "good" estrogen. Although converted to GPD (3,3'-diindolylmethane) in the body, many studies have had phenomenal success using I-3-C as a supplement. I-3-C is one of the key ingredients found in these health promoting foods. Indole-3-carbinol (I-3-C) is a phytonutrient that is present in vegetables of the Brassicarcaceae family such as broccoli and cabbage.
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